Human Type II Diabetes

Treatable with NPM-119

In the U.S., type II diabetes currently affects 1 in 10 people and is expected to affect 1 in 3 people by 2050 1. Drug sales for type II diabetes were $23.4 billion in 2010, with an expected increase to $45 billion by 2020 2. Often, the absence of immediate noticeable treatment benefit leads to inadequate patient compliance. The lack of adherence to type II diabetes treatments results in $24.6 billion in avoidable costs annually 3. Unfortunately, severe manifestations of the disease, including blindness, kidney failure, neuropathy, and death, do not occur until years of improper treatment. Due to the staggering economic costs associated with diabetes ($245 billion in the U.S. alone 1), stakeholders are actively seeking treatments that improve compliance, and as a result, health outcomes.

GLP-1 receptor agonists are an increasingly utilized class of drugs for treating type II diabetes. There are currently 5 marketed drugs in this class, all of which require frequent injections, representing more than $2 billion in 2013 global sales. The market size for GLP-1 agonists is expected to reach nearly $8 billion by 2020 (17% CAGR 4).

1 American Diabetes Association, Fast Facts 2013
2 Decision Resources
3 IMS Institute for Healthcare Informatics 2016
4 Research and Markets

Problems With Current Treatment

Drugs Do Not Work if Patients Do Not Take Them

  • Non-adherence is common

    Treatments can be complex and adherence to second-line Type 2 Diabetes therapies is, at best, 56%.

  • Current therapies do not work

    > 50% of patients do not meet target efficacy with current treatments, often because of poor adherence.

  • Non-adherence is expensive

    Non-adherence costs health care providers more than $5,000 in annual direct costs per patient (inpatient + outpatient)

How We Solve It

Only One Implant Is Necessary

  • Small device, simple insertion

    NanoPortal implantation can be performed in a quick, outpatient procedure.

  • Extended duration

    NanoPortal is being designed to last for durations of 4 months to 1 year.

  • Ensured compliance

    Implantation ensures continuous dosing for the duration of the treatment.

Pipeline overview
Feline Pre-diabetes and Diabetes